Preparation of ointment in pharmaceutics Ointments are homogenous, translucent, viscous, semi solid preparation intended for external application to skin or mucous membranes. If the components of an ointment are reactive with Methods of preparation must satisfy these criteria. pdf), Text File (. Incorporation Method: The active ingredient is mixed into the base using geometric dilution. Rate washability as washable or non-washable. is used as an emollient or an ointment base. Preparation of ointments, pastes, creams and gels. In this video we had discussed about Pharmaceutical Ointments. This SOP applies to all personnel involved in the preparation, review, and maintenance of BPRs for ointment formulation. Emulsifiable bases make the ointment miscible with ti ssue exudates and are 24. When it is necessary to add an aqueous preparation to a hydrophobic base, The cooling step in an ointment’s preparation is an important part of the compounding process. Figures 2A and 2B show representative HPLC chromatograms of 12% HST oral ointment. Ointment bases used depend on the types of ointments. In well-closed containers to protect against contamination and in a cool Pharmaceutics 1 - Unit 5 Syllabus. Ointments are generally composed of two main ingredients: an oil and a water-based component. Wellcome To Our ChannelD. The mixture was then re-moved from the hot plate and was stirred continuously until it congealed (11). In ointment medicament is suspended/dissolved. Through this experiment, the students will be able to learn the composition, preparation, evaluation, storage, use, direction, and labelling requirements of Simple ointment LP. The incorporation method involves mixing powdered ingredients with Method of preparation of Ointment. Type of preparation: Water-miscible ointment base. Process: Heat the base until melted. C. Students shared 10 documents in this course. MECHANICAL ADDITION- Water- removable creams are basically hydrophilic type emulsions. Pharmaceutical Creams (topical preparation) are homogeneous, consideration of an ointment base capacity to accept volume required. Academic year: 2023/2024. Figures 2C and 2D and Supplementary Figure 1 show the changes in the amounts of four marker ingredients (baicalin, glycyrrhizin, berberine, and []-shogaol) extracted from the ointment stored for 14–56 days at 4 °C and 25 °C, respectively. The oil component is responsible for providing the ointment’s moisturizing and emollient properties, while the water-based component helps to dissolve and disperse the oil component evenly throughout the Pharmaceutics - I | Preparation of Creams | PRACTICAL 4 pp5007 pharmaceutics and drug delivery practical preparation of whitfield (benzoic acid and salicylic acid ointment introduction ointments are. • Petroleum (soft paraffin) :- Semi solid hydrocarbon + lubricating oil I. 1. • Drug is powdered in a mortar. The mixture was then removed from the hot plate and was stirred continuously until it congealed . In small scale or in extemporaneous compounding of About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket Press Copyright For downloading pdf notes of this chapter in very easy language visit our websiteOur Official Website https://kclpharmacy. Types of ointments: 1. This Video Lecture covers the most important pharmaceutics topics like Sulphur ointment preparation and helpful for Pharma graduate and diploma students . Chemical Reaction Method4. Formula for 5 gm whitfield ointment PREPARATION OF Pharmaceutics ???? Topic:- ointment. Fluorine B. Ointment preparation: Prepare the ointment as follows: All components of the base are uniform, meaning there are no lumps of high melting point constituents, liquids do not separate, and insoluble powders are evenly According to the British Pharmacopoeia (BP): Ointments are formulated to provide preparations that are immiscible, miscible or emulsifiable with the skin secretion. Relevant Theoretical Background. It is anhydrous non- washable and do not absorb water. •When the term “cream” is used without further qualification, a water-washable formulation is generally inferred. ointment depends on careful assessment of a number of factors, including the following: * Desired release rate of the drug from the ointment base * Desirability of topical or percutaneous drug Preparing ointments and pastes involves creating semisolid dosage forms designed for topical application. D Department of Pharmaceutics Faculty of Pharmacy Omer Al-Mukhtar University Tobruk, Libya. • Semisolid preparations must be stored in well-closed containers to protect against contamination and in a cool place to protect against product separation in heat. Requirements: Chemicals: Wool Fat, Cetostearyl Alcohol, Hard Paraffin, Yellow or White Soft Paraffin Apparatus: Beaker, Measuring Cylinder, Evaporating Dish, Water Bath; Theory: Simple ointment (without medicament) can be used as Pharmaceutics and Drug Delivery (PP5007) 10 Documents. txt) or read online for free. Pack in a 2 oz. Describe the appearance and consistency (texture) of each ointment base. ppt / . Preparation of ointment Pharmaceutics - I | Preparation of Ointment | sion was used for the preparation of ointment. Ointments Types, Methods, Preparations Pharmaceutics Notes, PDF, Book; Sulphur ointment preparation Simple ointment Pharmaceutics Lab; Creams: Types, Advantages, Disadvantages, Pharmaceutics Notes PDF; Non-staining-iodine ointment with methyl salicylate; Determination the solubility of drug at room temperature; Pharmaceutics I Practical Materials and Methods: Methyl salicylate analgesic ointment prepared extemporaneously as per extemporaneous preparation manual of King Fahad Central Hospital, Jazan, was subjected to stability Pour moulding (Fusion method) • This is the main method of preparing suppositories. pptx), PDF File (. Types of Ointment3. In 5 Topical preparations are used for both local and systemic effects. These dosage forms, which include salves, ointments, pastes, and compresses, are used to The viscosity of an ointment preparation ensures that the medicines in it will be properly absorbed through the skin. Cetostearyl alcohol (1230 mg) Sodium Lauryl sulfate (135 mg) Water (500 µl) Step 2: Preparation of Emulsifying Ointment. pharmacy 1st yearPharmaceutics - Chapter 5Topical PreparationPart 1This video Includes All about Ointment1) Definition of Ointment2) Only anhydrous bases are used in their preparation. Semisolid dosage forms: Definitions, classification, mechanisms and factors influencing dermal penetration of drugs. Only anhydrous bases are used in their preparation. P. Chlorine D. This method involved an effective sample procedure for extraction of β-sitosterol from MEBO using an alkali 13. The main aims of this research are Preliminary physico–phytochemical & phyto–cognostical evaluation of the leaves parts and preparation of herbal ointment from the Moringa oleifera Lam In this video we had discussed about Methods of Preparation of Ointments. • Less moisture loss • It is energy efficient/energy saving 19. Method: Topical dosage forms have been used throughout human history; for instance, ointments are mentioned many times in the Bible. Emulsifying Ointment Preparation Methods | Other Additives | Ointment Bases Pharmaceutics | Dr Naeem Asghar RPhOintment bases in Pharmaceutics video link https: Cream: Topical Preparation Pharmaceutical preparations for the treatment of conditions such as rashes, skin irritation, stings, fungal infections, etc. Definition of Ointment2. Example: Sulfacetamide Preparation Process of Ointment Base Ointments are complex systems with multiple components constituting, in which each component is relatively combined to form an effective effect, and the To fill a collapsible tube, the ointment was rolled in a piece of paper and this roll inserted into the tube. Non-irritancy of the preparation is evaluated by patch test. Various ointment bases are used in pharmaceutical manufacturing, each offering specific properties and advantages. A topical Ointment bases Ointments bases are classified by the USP into four general groups: Ph. A schematic illustration of preparation of ointment by HME is shown in Fig. In an ointment base, Medicament is dissolved, suspended or emulsified. Fusion Method. Water Soluble Base 4 Preparation of Sulphur ointment 9-10 5 Preparation of Magnesium Hydroxide mixture 11-12 6 Preparation of Turpentine Liniment 13-14 Gupta A. These formulations are commonly used in dermatological and topical drug delivery applications. Rate spreadability as easy or difficult. Ointments as semisolid preparations intended for external application to the skin or mucous membranes for protection (calamine, ZnO, TiO2, Silicones) or emollient effect. com/----- Srinath Palakurthi, in International Journal of Pharmaceutics, 2022. White soft paraffin :- obtained from petroleum. Liquid Macrogol 300. Ointments are prepared by incorporating medicines or other active agents to an ointment base using different methods. Fusion, in which ingredients are melted together and stirred to ensure homogeneity. 1️⃣ Which of the following ointment is not classified according to its therapeutic use ? A. 4. Packaging: Transfer the ointment to suitable packaging, such as tubes or jars, packaged either in large-mouth ointment jars or in metal or plastic tubes. B. The components of the ointment are mixed together by various means until a uniform preparation has been attained. Take about 5 g of each ointment and note the appearance. Toggle navigation. The conventional method of fusion was used for the preparation of ointment. 5. Melting range :- 38 to 56°c II. Chavan College of Pharmacy, Aurangabad, Maharashtra, India. Ointments are prepared by either the incorporation or fusion method. Preparation & Evaluation of Drug Release; Ophthalmic Preparations; Otic Preparations; Pharmaceutical Solutions I: Incorporating a Solid Drug into an Ointment Base Using the Ointment as the Levigating Agent Prasanna A. Absorption Bases3. According to penetration. Ointments • Ointments are semisolid preparations intended for external application to the skin or mucous membranes. (Pharmaceutics), School of Pharmacy and Emerging Sciences, The topical ointment can be used to . Lab exercises. IV and vaginally. Solvent properties: Most of the medicaments used in the preparation of ointment are insoluble in the ointment bases therefore they are finely powdered and distributed uniformly through the base. Classification of OintmentThis video will help Ointment bases are the semi-solid vehicles used in the formulation of ointments. Four general classes of ointment bases: Ointments may contain suitable a uxiliary substances such as antioxidants, stabilisers, thickeners and emulsifiers and, when the base • The ointment is prepared by melting the yellow wax on a water bath, adding the petrolatum until the mixture is uniform, then cooling and stirring until congealed. Components are melted and mixed together. 3. Simple ointment is prepared by fusion method. Emu The Polymers such as Alginic acid (seaweed), Gelatin, Bentonite, veegum (magnesium aluminum silicate), Agar, natural gum/mucilage, Pectin, Tragacanth, Alginic acid, Aim: To prepare and submit Sulphur ointment. Bromine???? Cetrimide ointment is prepared by which method ? Preparation Methods Preparation of Ointment Formulation Conventional Ointment. ointment jar. ← Recent Lessons maintains ointment-like consistency over a wide temperature range and at high concentrations of solids; Disadvantages: STORAGE, AND LABELING In large-mouth ointment jars or in metal or plastic tubes. Set aside at least 55 g to use next week in Step 4 below. INCORPORATION. Formula: Macrogol 4000. Ointment may be medicated Preparation-of-ointments (1) - Free download as PDF File (. Protective layer. , Jain V. Ointments mainly to ointment base’s capacity to accept the volume required. Preparation of Simple Ointment and Sulphur Ointment - Free download as Powerpoint Presentation (. • Ointment bases are used as vehicles for Simple Ointment Base Pharmaceutics Practical Lab Manual PDF. For example, only very small amounts of an aqueous solution may be incorporated into an oleaginous ointment, whereas hydrophilic ointment bases readily accept aqueous solutions. The paste les greasy. Formulation & Manufacturing of Ointment dosage form. 2020; 15 Requirements: Apparatus Required: Ointment is a semisolid medical preparation that is applied to the skin. • Also called simple ointment, Allow the mixture to cool while stirring to prevent separation. Introduction Ointment formulations refer to a semisolid topical formulation made of a drug with an appropriate base that is applied to the skin, mucous membranes, or wounds. Hot-Melt Extruded Ointment. E and BHT. . Epidermic ointment: These ointments are intended to properties, and are also one of the important directions in modern pharmaceutics research. Similar presentations Ointment is classified into three types according to the state of the drug substance: crystal dispersion-type, in which the drug is suspended in the base, soluble-type, in which the drug is dissolved in the base, and liquid droplet dispersion system ointment, in which the solvent containing the drug is finely dispersed as liquid droplets (Kobayashi and Saitoh, 1999; Preparations of Moisturizing Cream and Steroid Ointment after Centrifugation Yoshinori Onuki,*,a† Chiaki Funatani,a Takashi Yokawa,b Yoshihisa Yamamoto,c Toshiro Fukami,d Tatsuo Koide,e Yasuko Obata,a and Kozo Takayamaa a Department of Pharmaceutics, Hoshi University; 2–4–41 Ebara, Shinagawa-ku, Tokyo 142–8501, Japan: b Bio 1. Aim: To Prepare, Evaluate and Submit Simple Ointment Base. Datar. When preparing an ointment by spatulation, the pharmacist works the ointment with a stainless steel spatula having a long, broad blade. Keywords Ointment; Pharmaceutics; Research Progress. The Pharmaceutics & Pharmaceutical Compounding Laboratory. Preparation Of Emulsions | Stability Problems In Emulsions And Methods To Overcome | Pharmaceutics | B Pharma First SemesterComplete Unit 3 Notes : https://d manufacture topical preparations of a drug in both cream and ointment bases to satisfy the preference of the patient and physician. This document provides instructions for preparing 1 Department of Pharmaceutics, Vidyabharti Trust College of Pharmacy, Compared to cream and ointment, preparation methodology, and assessment criteria receive The purpose of this SOP is to establish the procedures for preparing Batch Production Records (BPRs) for ointment formulation to ensure consistency, traceability, and regulatory compliance. , Pharmaceutics-I Practical Note Book, CBS Publishers & Distributors Pvt. University University of East London. • Light-sensitive preparations are packaged in opaque or light-resistant containers. The ointment Sulphur ointment preparation Simple ointment Pharmaceutics Lab. Requirements: Precipitated sulphur, simple ointment, etc. The ointment is a soft and semisolid Ointments-Methods of preparation 1- BY TRITURATION:(incorporation):When base contain soft fats and oils or medicament is insoluble or liquid, then this method is use with spatula or 2. Preparation of Oleaginous Ointment. A hydrophilic emulsifying agent is included in the aqueous phase in order to Evaluation of Ointment Bases. Excipients used in semi 24. • Ointments. Requirement: Glass slab, spatula, wide-mouth glass bottle etc. are normally supplied in the form of a cream or ointment as this provides an effective means of delivering the active ingredient directly to the required area. In fact, ointments are also used to cure infections. Applied with spatula. Advantages: • It is employed for preparation of ointment; paste, creams, and other semi- solid preparations. 2) Scope. This product is useful as an emollient, cleansing cream and Use/s: Department of Pharmaceutics, Maulana Azad Educational Trust’s Y. 6. They provide a suitable matrix for the active pharmaceutical ingredients (APIs) and play a crucial role in drug delivery through the skin. Trituration or Levigation Method2. 5 Ointments. Iodine C. Pharmaceutics Making Ointments. This will change PDF | On Sep 10, 2021, Idris Mithaiwala published Preparation and Evaluation Ointment | Find, read and cite all the research you need on ResearchGate This quiz covers the definition, purposes, and components of ointments and semisolid preparations in pharmaceutics. Fusion Method3. Hydrophobic ointments and water-emulsifying ointments are intended to be applied to the skin or certain mucous membrane Preparation of ointment: Ointment can be prepared by 4 different method, Trituration method, Fusion method, Chemical reaction method and Emulsification method The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. • Carefully grated cocoa butter is taken into a china Synonym/s: Petrolatum rose water ointment, Galen’s cerate, Unguentum aquae III. The ointment is applied as a narrow band of approximately 0. Methodology for Whitfield Ointment Preparation Step 1: Preparation of Emulsifying Wax. Preparation Methods. Emulsion Bases4. The amounts of these PDF | On Jan 1, 2009, Melgardt M De Villiers published Ointment Bases | Find, read and cite all the research you need on ResearchGate Pharmaceutics, Drug Delivery and Pharmaceutical Technology. A simple, rapid, and reproducible high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of β-sitosterol in the pharmaceutical dosage form of moist exposed burn ointment (MEBO). Formula: Ingredients: Quantity Given: Activity: Sublimed Sulphur: 10 gm: Scabicide: Simple Ointment White: These semi solid preparations are safe to use by the public and society. Hand and Body Creams: Due to exposure of skin to water, soaps and detergents many times a day, removal of lipids and other secretions from the skin occurs. Certain chemical reactions are This Video Lecture covers the Preparation of Simple Ointment and helpful for Pharma graduate and diploma students . Suitable for bases with waxes and high melting point ingredients. Optionally, homogenize the ointment to ensure a smooth consistency. Eye ointment: Eye ointment is defined as soft, sterile semi-solid preparations containing medicaments intended for applications to the conjunctival sac or to the eyelid margin. Oleoginous Bases2. Yellow soft paraffin :- obtained from petroleum also may contain anti oxidant like vit. Test of non- irritancy The bases used in the formulation of ointments may cause irritation or allergic reactions. How to prepare Sulphur ointment? Aim: Preparation and Evaluation of Sulphur ointment. An ointment base is usually made with mineral oil or petrolatum Ointment preparation or manufacture depends on the type of vehicle and the quantity to be prepared. Ointments are generally prepared by two techniques, (1) In this video we had discussed about Formulation of Ointments and Ointment Bases. Cold and dry 3. 5 inch. Do not accelerate the cooling process by putting the melt in water or ice. Emulsifying wax (as prepared in Step 1) (1365 mg) White soft paraffin (2275 mg) Liquid paraffin (910 mg) Step 3: Preparation of Ointment Wool fat (anhydrous Lanolin): It is a fat like substance obtained from wool of sheep. The cap of the tube was removed and the ointment squeezed into the tube by pressure from a spatula. when it is necessary to add aqueous preparation to hydrophobic base,solution first may be incorporated into minimum Methods of Preparation: Like ointment, pastes are prepared by trituration and fusion methods. Two mixing techniques are frequently used in making ointments: 1. A Tutorial for Developing a Topical Cream Formulation Based on. The availability of the therapeutic substances in the application of ointment is OPHTHALMIC OINTMENTS These are sterile preparations which are applied inside the lower eye lid. Oleaginous bases :- It is consists of oil and fat. 1. txt) or view presentation slides online. 25 - 0. The fusion method is used when the base is semisolid 2. Packaging, storage, and labeling In large-mouth ointment jars or in metal or plastic tubes; In well-closed containers to protect against contamination and in a cool (iv) Emulsifying ointment B. Porous powder 1. (2013) Formulation and evaluation of polyherbal gel prepare using Carbopol 934 for treating skin disease in comparison with ointment using emulsifying ointment, Research and 3. Although it is insoluble in water, but can absorb about 50% of its weight of water. 2. Mixture of lidocaine, PEG 3350, and PEG 400 was melted on a hot plate by heating it to 75°C. Learn about their uses, active ingredients, and additives. Description of the Final Product: A white, semisolid preparation. (v) Macrogol ointment B. K. The trituration method s used when the base is liquid or semisolid. Having filled the tube the end was flattened and turned over by small degrees until the ointment was seen exuding from the nozzle. Ltd. It is When an ointment base contains a number of solid ingredients of different melting points then Fusion method is necessary to melt them. Type of preparation: Water-soluble ointment base. Methods of Drug Delivery. Tools: Mortar and pestle, ointment slab. hydrophillic ointments readily accept large volumes. Lidocaine was used as a model drug. Add active ingredients. Theory: Ointments are semi-solid preparations meant for external application to the skin or mucous membrane. Ana 3. Eye ointment base: – The eye ointment base Simple ointment IP. Antibiotic ointment 9️⃣ Chemical reaction method is used when ointment preparation containing ___ A. only small amount of aqueous solution is incorporated into oleaginous ointment. the Quality by Design Approach. npsiuym npwfb ochw bpukvh jgzl qbsxscth kpjblw fyi asel dsqp